1,4-Dioxane

Chemical Name: CAS #:
Hazard Classification:
Location Used: Principal Investigator:
Processes for Which Chemical Is Used:
HAZARDS AND PROTECTION
Hazard Information
• Highly flammable
• Causes serious eye irritation
• May cause respiratory irritation
• Suspected of causing cancer
• Peroxide-forming solvent
Routes of Exposure
• Ingestion ● Skin Absorption
• Inhalation
• Eye absorption
If exposed by:
• Inhalation: Remove to fresh air
• Ingestion: Do not induce vomiting, rinse
mouth with water
• Eye or skin: Rinse affected area for 15
minutes
If exposed by any route, seek medical attention.
Exposure Limits
All exposure limits are Time Weighted Averages
(average exposure over an eight-hour day).
OSHA PEL: 25 ppm (90 mg/m3
)
ACGIH TLV: 20 ppm (72 mg/m3
)
Engineering Controls
• Chemical Fume Hood Never open 1,4-dioxane outside of a chemical fume
hood.
Administrative Controls
• Designated area sign
• Particularly hazardous substance label
• Post designated area sign before each use.
• Label containers of 1,4-dioxane as a health
and physical hazard.
• Use as small a quantity as possible.
1,4-Dioxane 123-91-1
Health and Physical Hazard
ARKANSAS STATE UNIVERSITY EHS
LABORATORY CHEMICAL STANDARD OPERATING PROCEDURE
CS-015 Last Reviewed December 16, 2019
Personal Protective Equipment
• Gloves
• Safety glasses or splash goggles
• Lab coat
Two pairs of nitrile gloves for short-term use. If longer
term use, butyl rubber gloves are required. Change
gloves immediately if a spill on gloves is observed.
Wash hands after use.
OTHER SAFETY INFORMATION
Transportation Follow guidance given in the laboratory safety manual
for transport of chemicals.
Storage
• Store in a flammables materials storage
cabinet.
• Keep away from heat or sources of ignition
• Keep tightly sealed
• Monitor for formation of explosive peroxides
Incompatible materials include:
Oxygen, oxidizing agents, halogens, reducing agents,
perchlorates, trimethylaluminum
Spill/Accident Procedures
For all spills:
• Wear two pairs of nitrile gloves
• Turn off sources of ignition (if safe)
• Evacuate the immediate area
Exposure:
• If anyone exposed requires emergency
medical attention, dial 911 (or 9-911 from
landline).
• Follow procedures outlined in laboratory
safety manual.
Small spills (less than 500 mL): Cover the spill with
absorbent materials. Place absorbent materials in bag
or bucket for collection by EHS. Clean area with soap
and water once spill is removed.
Large spills (greater than 500 mL): If the spill is in a
chemical fume hood, contact the EHS director (864-
710-2933). If he cannot be reached (does not answer
phone, do not leave voicemail), then call 911, pull the
fire alarm and exit the building. If the spill is outside of
a hood, then call 911, pull the fire alarm and exit the
building.
Waste Disposal Waste 1,4-dioxane must be collected for disposal.
Empty bottles of 1,4-dioxane may be rinsed and
thrown in the dumpster.
By signing below, you indicate that you have reviewed this SOP and understand the contents thereof